The Madhani lab is part of the Tetrad, BMS, Biophysics, and BMI PhD programs at UCSF. Students interested in a lab rotation are encouraged to contact Hiten directly at  The Madhani lab expects to recruit at least one graduate student in 2018-9.



The Madhani lab is currently accepting applications.  We work in both yeast (Cryptococcus) and mammalian systems. Apply by sending a CV that includes a list of publications and the contact information for three references to the laboratory’s administrative assistant, Ethel Godonoo (  Academically oriented fellows are encouraged to develop independent projects.  Individuals with a background in a quantitative discipline (applied mathematics, physics, engineering) as well as those with more traditional backgrounds in biology and chemistry are welcome to apply. Competitive salaries and benefits are offered.  UCSF subsidized housing is available. Supplements are available for fellows with children. Individuals from underrepresented groups are encouraged to apply.  Specific areas of interest are listed below.  

Evolutionary epigenomics

We are recruiting a postdoctoral fellow to investigate the evolution of gene silencing mechanisms (DNA methylation, RNAi, and Polycomb) in the Cryptococcus species complex. This group of organisms provides unique opportunities to understand the genetic conflicts between transposable elements and host silencing systems. The ideal applicant will have a background in evolutionary biology, genomics, epigenetics, or genetics as well as computational skills. 

Quantitative biology of epigenetic inheritance

We are recruiting a postdoctoral fellow to examine the mechanisms underpinning the stability of epigenetic states mediated by DNA methylation. Despite decades of research, the mechanisms that enable high-fidelity inheritance of cytosine methylation patterns remain poorly understood.  Cryptococcus neoformansprovides a unique yeast system in which to investigate these questions using quantitative methods and mathematical modeling and to apply this knowledge to mammalian systems. The ideal applicant will have a background in genomics or genetics as well as quantitative skills. 

Unbiased approaches to host-pathogen interactions

We are recruiting a postdoctoral fellow to use unbiased genetic, proteomic, and/or chemical approaches to understand what determines the outcomes of host-pathogen interactions using Cryptococcusand other pathogenic fungi as probes of the innate immune system. Compared to our understanding of bacterial and viral pathogen, we have a poor understanding of how fungal pathogens are sensed by and how they evade innate immunity. The ideal applicant will have a background in cellular immunology (including but not limitd to inflammasome biology, nucleic acid sensing or immunometabolism), genomics, or microbiology.