Welcome to the website for the Madhani laboratory in the Department of Biochemistry and Biophysics. We are located in Genentech Hall at the UCSF Mission Bay Campus. We are affiliated with the Tetrad graduate program, iPQB graduate program, the California Institute for Quantitative Biosciences (qb3) and the Helen Diller Family Comprehensive Cancer Center.
Chromatin biology is a major focus of the laboratory with interests in how silent domains are formed and regulated by histone modifications, histone variants and noncoding RNAs. The laboratory also has a longstanding pursuit of signal transduction, with a particular focus on mechanisms responsible for fidelity and precision in MAP kinase signaling. More recently, the laboratory has begun to develop tools to uncover mechanisms of pathogenesis by an opportunistic human fungal pathogen responsible for over a half million deaths annually in the HIV/AIDS population.
Example of our publications in each of these areas can be found on the right.