Signaling Publications
Bao, M.Z., Schwartz, M.A., Cantin, G.T., Yates, J.R. 3rd, Madhani, H.D. (2004). Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast. Cell 119: 911-1000. [PDF]
Schwartz, M.A. and Madhani, H.D. (2004) Principles of MAP Kinase Signaling Specificity in Saccharomyces cerevisiae. Annual Review of Genetics 38:724-748. [PDF]
Kung C., Kenski, D.M., Dickerson, S.H., Howson, R.W., Kuyper, L.F., Madhani, H.D., Shokat, K.M. (2005) Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor. Proc. Natl. Acad. Sci. USA 102: 3487-3592. [PDF]
Schwartz, M.A. and Madhani, H.D. (2006) Control of MAPK signaling specificity by a conserved residue in the MEK-binding of the yeast scaffold protein Ste5. Current Genetics 49:351-363. [PDF]
Kung, C., Kenski, D.M., Krukenbeg, K., Madhani, H.D., and Shokat, K.M. (2006) Selective kinase inhibition by exploiting differential pathway sensitivity. Chemistry and Biology 13, 399-407. [PDF]
Madhani, H.D. (2006). Functional analysis of protein kinase networks in living cells: beyond “knock-outs” and “knock-downs”. Methods 40: 251-4. [PDF]
Cantin, G.T, Shock, T.R., Madhani, H.D., and Yates, J.R. IIIrd (2007) Optimizing TiO2-based phosphopeptide enrichment for automated multidimensional liquid chromatography coupled to tandem mass spectrometry. Analytical Chemistry 79: 4666-4673. [PDF]
Shock, T.R. & Madhani, H.D. (2009). Hog1 MAP kinase interrupts signal transduction between the Kss1 MAP kinase and the Tec1 transcription factor to maintain pathway specificity. Eukaryotic Cell 8: 606-616. [PDF]
Bao, M.Z, Shock, T.R., Madhani, H.D. (2010) Multisite phosphorylation of the Saccharomyces cerevisiae filamentous growth regulator Tec1 is required for its recognition by the E3 ubiquitin ligase adaptor Cdc4 and its subsequent destruction in vivo. Eukaryotic Cell 9: 31-36 [PDF]
McCullagh, E., Seshan, A., El-Samad, H., Madhani, H.D. (2010) Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway. Nature Cell Biology, 12: 954–962. [PDF]
